Annual report pursuant to Section 13 and 15(d)

Federal Income Tax Provision Compared With Statutory Rates (Detail)

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Federal Income Tax Provision Compared With Statutory Rates (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Statutory regular federal income tax rate (21.00%) (21.00%) (21.00%)
Change in valuation allowance 34.20% 6.80% 35.00%
State tax benefit (net of federal benefit) (4.80%) (4.80%) (7.00%)
Research credits (0.60%) 0.60% 2.10%
Foreign amounts with no tax benefit 0.00% 0.10% 0.00%
Non-deductible expenses (4.20%) (4.10%) 2.40%
Effect of change in rate 0.00% 9.70% (20.00%)
Expired net operating loss carryforwards 0.00% 3.70%
Effect of prior year true-ups 4.30% 22.80% 0.00%
Other (1.10%) (0.70%) 2.60%
Total (0.40%) (0.70%) 0.40%