Quarterly report pursuant to Section 13 or 15(d)

Assumptions Used in Estimating Fair Value of Stock Options Granted (Detail)

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Assumptions Used in Estimating Fair Value of Stock Options Granted (Detail) - 2002 Stock Incentive Plan
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]        
Expected term 5 years 3 months 18 days 5 years 10 months 24 days 5 years 6 months 5 years 9 months 18 days
Volatility 80.50% 86.60% 78.70% 85.50%
Risk-free interest rate 1.76% 1.30% 1.95% 1.32%